Publications

P. Bittihn, L. S. Tsimring, Gene Conversion Facilitates Adaptive Evolution On Rugged Fitness Landscapes, Genetics 207, 1577 (2017), doi:10.1534/genetics.117.300350

Y. Li, M. Jin, R. O'Laughlin, P. Bittihn, L. S. Tsimring, L. Pillus, J. Hasty, N. Hao, Multi-generational silencing dynamics control cell aging, PNAS 114, 11253 (2017), doi:10.1073/pnas.1703379114 

A. Mayer, P. Bittihn, S. Luther, Complex restitution behavior and reentry in a cardiac tissue model for neonatal mice, Physiological Reports 5, e13449 (2017) doi:10.14814/phy2.13449

P. Bittihn*, S. Berg*, U. Parlitz, S. Luther, Emergent dynamics of spatio-temporal chaos in a heterogeneous excitable medium, Chaos 27, 093931 (2017), doi:10.1063/1.4999604

S. R. Scott, M. O. Din, P. Bittihn, L. Xiong, L. S. Tsimring, J. Hasty, A stabilized microbial ecosystem of self-limiting bacteria using synthetic quorum-regulated lysis. Nature Microbiology 2, 17083 (2017), doi:10.1038/nmicrobiol.2017.83

P. Bittihn, J. Hasty, L. S. Tsimring, Suppression of Beneficial Mutations in Dynamic Microbial Populations. Physical Review Letters 118, 028102 (2017), doi:10.1103/PhysRevLett.118.028102

T. K. Shajahan, S. Berg, S. Luther, V. Krinski and P. Bittihn, Scanning and resetting the phase of a pinned spiral wave using periodic far field pulses. New Journal of Physics 18, 043012 (2016), doi:10.1088/1367-2630/18/4/043012

P. Bittihn, Complex Structure and Dynamics of the Heart, Springer International Publishing (2015)doi:10.1007/978-3-319-12232-8

P. Bittihn, Chaos in the heart – heart rhythm disorders from a physical point of view – perspectives for an aging society? Essay for the "Deutscher Studienpreis" for Ph.D. theses with societal impacts, selected as second prize nationwide, Körber foundation (2014) Read the essay and about the prizes (in German)

P. Bittihn, M. Hörning, D. Hornung, F. H. Fenton, S. Luther, Electric-Field-Based Control Strategies for Cardiac Tissue, Biophysical Journal 104, Issue 2, Supp. 1, 153a–154a (2013), doi:10.1016/j.bpj.2012.11.869

J. Menzel, P. Weil, P. Bittihn, D. Hornung, N. Mathieu and S. Y. Demiroglu, Requirement analysis for an electronic laboratory notebook for sustainable data management in biomedical research. Studies in Health Technology and Informatics 192, 1108 (2013), doi:10.3233/978-1-61499-289-9-1108

P. Bittihn, M. Hörning, S. Luther, Negative curvature boundaries as wave emitting sites for the control of biological excitable media, Physical Review Letters 109, 118106 (2012), doi:10.1103/PhysRevLett.109.118106 Editor's Choice

S. Luther*, F.H. Fenton*, B.G. Kornreich, A. Squires, P. Bittihn, D. Hornung, M. Zabel, J. Flanders, A. Gladuli, L. Campoy, E.M. Cherry, G. Luther, G. Hasenfuss, V.I. Krinsky, A. Pumir, R.F. Gilmour Jr., E. Bodenschatz, Low-energy control of electrical turbulence in the heart, Nature 475, 235-239 (2011), doi:10.1038/nature10216

S. Petitprez, A. F. Zmoos, J. Ogrodnik, E. Balse, N. Raad, S. El-Haou, M. Albesa, P. Bittihn, S. Luther, S. E. Lehnart, S. N. Hatem, A. Coulombe, H. Abriel, SAP97 and Dystrophin Macromolecular Complexes Determine Two Pools of Cardiac Sodium Channels Nav1.5 in Cardiomyocytes, Circulation Research 108 (2011), doi:10.1161/CIRCRESAHA.110.228312

A. Behrend, P. Bittihn, S. Luther, Understanding and predicting the response of pinned vortices to periodic electric far-field stimuli, Biomedical Engineering 55 Supp. 1 (2010), doi:10.1515/bmt.2010.712

A. Behrend, P. Bittihn, S. Luther, Predicting Unpinning Success Rates for a Pinned Spiral in an Excitable Medium, Computing in Cardiology 37, 345 (2010), article on ieeexplore

P. Bittihn, A. Squires, G. Luther, E. Bodenschatz, V. Krinsky, U. Parlitz, and S. Luther, Phase-resolved analysis of the susceptibility of pinned spiral waves to far-field pacing in a two-dimensional model of excitable media, Phil. Trans. R. Soc. A 368, 2221-2236 (2010), doi:10.1098/rsta.2010.0038

P. Bittihn, Control of Spiral Wave Activity in Excitable Media, Diploma Thesis, Georg-August University, Göttingen, Germany (2009)

P. Bittihn, G. Luther, E. Bodenschatz, V. Krinsky, U. Parlitz and S. Luther, Far field pacing supersedes anti-tachycardia pacing in a generic model of excitable media, New Journal of Physics 10, 103012 (2008), doi:10.1088/1367-2630/10/10/103012

J. Klein, A. Vilanova , P. Ledochowitsch, P. Bittihn, H. K. Hahn, O. Konrad, J. Rexilius, H.-O. Peitgen, Improving Interaction and Perception of Brain Structure using Fiber Clustering. SPIE Newsroom Biomedical Optics & Medical Imaging, 1-3 (2007) doi:10.1117/2.1200707.0771

J. Klein, P. Bittihn, P. Ledochowitsch, H. K. Hahn, O. Konrad, J. Rexilius and H.-O. Peitgen, Grid-based spectral fiber clustering, Proc. SPIE 6509, 65091E (2007) doi:10.1117/12.706242

*equal contribution
corresponding author

Talks

"Stabilizing engineered microbial populations — about the benefit of being dynamic" — P. Bittihn, August 2017, Max Planck Institute for Terrestrial Microbiology, Marburg, Germany (invited)

"Bacterial populations that change size — new effects and applications" — P. Bittihn, August 2017, Max Planck Institute for Dynamics and Self-Organization, Göttingen, Germany (invited)

"Adding Dynamics to the (Synthetic) Biology Mix – New Effects and Applications" — P. Bittihn, Collins Lab, July 2017, MIT, Cambridge, MA, USA

"Using Bistability, Oscillations and Slow-Fast Dynamics to Engineer Population Density Control and Stable Coexistence of Competitive Bacterial Strains" — P. Bittihn, SIAM Conference on Applications of Dynamical Systems 2017, Snowbird, UT, USA

"Sensing the Environment through a Protective Shield – Phenotypic Entrainment of a Synthetic Gene Oscillator" — P. Bittihn, M. E. Dueck, L. Xiong, L. S. Tsimring, and J. Hasty, Winter Q-Bio 2017, Kauai, HI, USA

“Suppression of beneficial mutations in dynamic microbial populations” — P. Bittihn, J. Hasty and L. Tsimring, The SDCSB’s Quarterly Systems-to-Synthesis Meeting: Spring 2016, La Jolla, CA, USA

“A Mechanism of Spiral Wave Unpinning and Its Implications for the Treatment of Cardiac Arrhythmias with Periodic Far-Field Pacing” — P. Bittihn, A. Behrend and S. Luther, SIAM Conference on Applications of Dynamical Systems 2015, Snowbird, UT, USA (invited)

“The Role of Cardiac Structural Heterogeneity during Electric-Field Stimulation” — P. Bittihn, High Definition Physiology Project Symposium 2013, Tokyo, Japan (invited)

“The Role of Cardiac Structural Heterogeneity during Electric-Field Stimulation” — P. Bittihn, Keio University, June 2013, Japan (invited)

“The Role of Cardiac Tissue Anatomy during Electric-Field Stimulation” — P. Bittihn, SIAM Conference on Applications of Dynamical Systems 2013, Snowbird, UT, USA (invited)

“Theory and Application of Low-Energy Pacing Strategies for the Control of Cardiac Dynamics” — P. Bittihn, Annual Meeting of the German Biophysical Society, 2012, Göttingen, Germany

“Cardiac tissue heterogeneity mediates electrical stimulation effects” — P. Bittihn, M. Hörning, S. Luther, BioCircuits Institute, UCSD, May 2012, San Diego, CA, USA

“Cardiac tissue heterogeneity mediates electrical stimulation effects” — P. Bittihn, M. Hörning, S. Luther, 12th Experimental Chaos and Complexity Conference, 2012, Ann Arbor, MI, USA

“Dynamical impact of structural heterogeneities in electrically-stimulated cardiac tissue” — P. Bittihn, M. Hörning, S. Luther, DPG Spring Meeting, 2012, Berlin, Germany

“Dynamical response of cardiac tissue to electric-field stimulation” — P. Bittihn, D. Hornung, S. Richter, S. Luther, Dynamics Days Europe, 2011, Oldenburg, Germany

“Low-Energy Control of Cardiac Dynamics: Virtual Electrode Formation at Tissue Boundaries” — P. Bittihn, D. Hornung, S. Luther, International Scientific Conference on Physics and Control, 2011, León, Spain

“Control of Spiral Wave Activity in Excitable Media with Application to Cardiac Dynamics” — P. Bittihn, Lecture at ICTS BioModVis Workshop 2010, Jacobs University, Bremen, Germany

“Lyapunov Stability Analysis of Generic Activation Patterns in Excitable Media” — P. Bittihn, U. Parlitz, S. Luther and F. Fenton SIAM Conference DSPDEs 2010, Barcelona , Spain

“Control of Spiral Wave Activity in Heterogeneous Excitable Media” — P. Bittihn, E. Bodenschatz, V. Krinsky, U. Parlitz and S. Luther, Dynamics Days Europe 2009, Göttingen, Germany

 “Far field pacing supersedes anti-tachycardia pacing in a generic model of excitable media” — P. Bittihn, U. Parlitz, E. Bodenschatz, V. Krinsky and S. Luther, SIAM Conference on Applications of Dynamical Systems 2009, Snowbird, UT, USA

“Two mechanisms for Control of Chaos in the Heart Induced by Pinned Rotating Waves” — P. Bittihn, G. Luther, U. Parlitz, E. Bodenschatz, V. Krinsky and S. Luther, 10th Experimental Chaos Conference, 2008, Catania, Italy

“Pattern Control in a Two-Dimensional Model of Cardiac Tissue” — P. Bittihn, U. Parlitz and S. Luther, DPG Spring Meeting, 2008, Berlin, Germany

Posters

"Suppression of Beneficial Mutations in Dynamic Microbial Populations" — P. Bittihn, J. Hasty, L. S. Tsimring, Gordon Research Conference on Stochastic Physics in Biology, January 7-13, 2017, Ventura, CA, USA

“Sensing the Environment through a Protective Shield – Phenotypic Entrainment of a Synthetic Oscillator” — P. Bittihn*, M. E. Dueck*, L. Xiong, L. S. Tsimring and J. Hasty, 2016 Postdoc Research Symposium, November 1, 2016, La Jolla, CA, USA

“Interplay of stochasticity and dynamics in mutating populations” — P. Bittihn, J. Hasty and L. Tsimring, 2015 Postdoc Research Symposium, September 14, 2015, La Jolla, CA, USA

“Interplay of stochasticity and dynamics in mutating populations” — P. Bittihn, J. Hasty and L. Tsimring, 15th HFSP Awardees Meeting, Salk Institute for Biological Sciences, July 12-15, 2015, La Jolla, CA, USA

“Combining Ontology Design and Flexible Data Management in Biomedical Sciences” — T. Fitschen, A. Schlemmer, D. Hornung, P. Bittihn, J. Schröder-Schetelig, U. Parlitz and S. Luther, German Conference on Bioinformatics 2013, September 10-13, 2013, Göttingen, Germany

“Requirement Analysis for an Electronic Laboratory Notebook for Sustainable Data Management in Biomedical Research” — J. Menzel, P. Weil, P. Bittihn, D. Hornung, N. Mathieu, S. Y. Demiroglu, MedInfo 2013, August 20-23, 2013, Copenhagen, Denmark

“The CPVT1 cardiac substrate shows conduction slowing similar to LQTS3 uncovering a potential arrhythmia mechanism” — M. Dura, P. Bittihn, S. Luther, S. Lehnart, 78th Annual Meeting of the German Cardiac Society (DGK), April 11-14, 2012, Mannheim, Germany

“Quantitative Evaluation of Cardiac Conduction Defects Using Optical Mapping in a Model of Muscular Dystrophy” — N. Raad, P. Bittihn, S. Lehnart, S. Luther, 78th Annual Meeting of the German Cardiac Society (DGK), April 11-14, 2012, Mannheim, Germany

“Electric-field based control strategies for cardiac tissue” — P. Bittihn, M. Hörning, D. Hornung, F. H. Fenton, S. Luther, 57th Annual Meeting of the (US) Biophysical Society, 2013, Philadelphia, PA, USA

“High‐resolution Characterization of Whole Heart Structure and Dynamics” — D. Hornung, P. Bittihn, J. Schröder-Schetelig, T. Baig, A. Squires, E. Bodenschatz, F. Fenton, and S. Luther, EUTrigTreat General Assembly, June 22-24, 2011, Utrecht, The Netherlands 

“Mechanisms of Conduction Disease in the Dystrophin Deficient Mouse Model of Duchenne Muscular Dystrophy” — N. Raad, P. Bittihn, S.E. Lehnart, and S. Luther, EUTrigTreat General Assembly, July 7-10, 2010, Glasgow, U.K.